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Document Type
Table
Review Code
EOC211201 RR Table
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Document Type
Table
Review Code
EOC211201 RR Table
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Badea, A; Reeder, B; Groot, G; Muhajarine, N; Minion, J; Miller, L; Howell-Spooner, B. In real world settings, what is the validity of Rapid Antigen Tests (RATs) in identifying SARS-CoV-2 and how well do they predict disease? 2022 Jan 12, Document no.: EOC211201 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. (CEST table).
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EOC211201 RR Table

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Document Type
Rapid Review
Review Code
EOC211201 RR
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC211201 RR
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Key Findings
January 12, 2022
The diagnostic accuracy of Rapid Antigen Tests (RAT) has been widely studied in various applications and in diverse populations.
Sensitivity, in the order of 75% in pooled estimates, is significantly influenced by the presence or absence of symptoms, viral load, and the timing of sampling relative to the onset of symptoms.
Specificity, in the order of 99% in pooled estimates, is consistently high across tests, populations, and sampling methods.
Post-test probability of being an infectious case following a positive test is highest in individuals with a high pre-test probability (population prevalence > 5%), such as those with COVID-19 symptoms, and those in settings with a high level of community transmission. Here, the positive predictive value is in the order of 95%. However, when used in settings with a lower pre-test probability (population prevalence < 0.5%), as in screening asymptomatic individuals, the positive predictive value is considerably reduced, as low as 25%.
Post-test probability of being an infectious case following a negative test is less than 1% (negative predictive value > 99%) in all settings except those with the highest levels of community transmission.
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Badea, A; Reeder, B; Groot, G; Muhajarine, N; Minion, J; Miller, L; Howell-Spooner, B. In real world settings, what is the validity of Rapid Antigen Tests (RATs) in identifying SARS-CoV-2 and how well do they predict disease? 2022 Jan 12, Document no.: EOC211201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 15 p. (CEST rapid review report).
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Document Type
Evidence Search Report
Review Code
EOC211201 ESR
Question Submitted
December 23, 2021
Date Completed
December 29, 2021
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC211201 ESR
Question Submitted
December 23, 2021
Date Completed
December 29, 2021
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Miller, L. & Howell-Spooner, B. In real world settings, what is the validity of RATs in identifying COVID-19 (sensitivity, specificity), and how well do they predict disease (positive and negative predictive values)? 2021 Dec 29, Document no.: EOC211201 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 56 p. (CEST evidence search report).
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Document Type
Evidence Search Report
Review Code
EOC211201-02 ESR
Question Submitted
December 23, 2021
Date Completed
January 5, 2022
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC211201-02 ESR
Question Submitted
December 23, 2021
Date Completed
January 5, 2022
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Variants
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Miller, Lukas. Howell-Spooner, Brianna. Omicron Variant: In real world settings, what is the validity of RATs in identifying COVID-19 (sensitivity, specificity), and how well do they predict disease (positive and negative predictive values)? 2022 Jan 05. Document no.: EOC211201-02 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 12 p. (CEST rapid review report).
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Document Type
Evidence Search Report
Review Code
EOC081201-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC081201-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
Category
Administration
Epidemiology
Subject
Reopening
Schools
Transmission
Public Health
Decision Making
Population
All Pediatrics
Priority Level
Level 4 completed within 1 week
Cite As
Dalidowicz, M; Ellsworth, C. What COVID-19 community transmission indicators are used in school reopening plans? 2020 Aug 12; Document no.: EOC081201-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 12 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
EOC081201 RR
Question Submitted
August 12, 2020
Date Completed
August 26, 2020
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC081201 RR
Question Submitted
August 12, 2020
Date Completed
August 26, 2020
Status
3. Completed
Research Team
EOC
Key Findings
· Potential impact on reproductive rate (R) of the seven “returning to school” scenarios that were modeled by SAGE exhibited an increase in R due to reopening of school. The scale of increase depended on current value of R within each community and mitigation plans within the community, especially the adherence to social distancing measures. · CDC recommended using additional indicators such as healthcare capacity, new cases, and percent of positive cases to decide school operations along with community spread levels: none-to-minimal, minimal-to-moderate, substantial-controlled, and substantial-uncontrolled. · Combination of strategies such as mask usage, physical distancing, hygiene measures, classroom cohorting, symptomatic screening, testing and tracing of students, staff and teachers along with low levels of community transmission can aid in maintaining low level of R. · Increasing testing and contract tracing can impede an epidemic rebound. · Intersectoral partnerships with local authorities, dedicated personnel (such as coordinators) for testing and tracing along with appropriate communication with parents, teachers and staff should be followed to open schools safely.
Category
Administration
Epidemiology
Subject
Reopening
Schools
Transmission
Public Health
Decision Making
Population
All Pediatrics
Priority Level
Level 4 completed within 1 week
Cite As
Pisolkar, V; McRae, D; Muhajarine, N; Dalidowicz, M; Ellsworth, C. What COVID community transmission indicators are used in school reopening plans? 2020 Aug 26; Document no.: EOC081201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 23 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
LAB042202-01 ESR
Question Submitted
April 22, 2020
Date Completed
23-Apr-2020
Status
3. Completed
Research Team
Laboratory
Document Type
Evidence Search Report
Review Code
LAB042202-01 ESR
Question Submitted
April 22, 2020
Date Completed
23-Apr-2020
Status
3. Completed
Research Team
Laboratory
Category
Diagnostics
Epidemiology
Subject
Testing
Public Health
Population
All
Clinical Setting
Community
Priority Level
Level 3 completed within 2-3 days
Cite As
Howell-Spooner, B. What frequency of repeat population screening will be required? 2020 Apr 23; Document no.: LAB042202-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 40 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
LAB042202 RR
Question Submitted
April 22, 2020
Date Completed
April 25, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB042202 RR
Question Submitted
April 22, 2020
Date Completed
April 25, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
Low grade evidence suggests that SARS-CoV-2 may persist within a population and lead to recrudescent outbreaks in winter months which may include the re-infection of previously infected individuals. · Population monitoring by means of repeated cross-sectional surveys and/or longitudinal cohort studies is strongly advised by WHO
Category
Diagnostics
Epidemiology
Subject
Testing
Public Health
Population
All
Clinical Setting
Community
Priority Level
Level 3 completed within 2-3 days
Cite As
Wang, H; Reeder, B; Howell-Spooner, B. What frequency of repeat population screening will be required? 2020 Apr 25; Document no.: LAB042202 RR. In: COVID19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 4 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
LAB042201-01 ESR
Question Submitted
April 22, 2020
Date Completed
23-Apr-2020
Status
3. Completed
Research Team
Laboratory
Document Type
Evidence Search Report
Review Code
LAB042201-01 ESR
Question Submitted
April 22, 2020
Date Completed
23-Apr-2020
Status
3. Completed
Research Team
Laboratory
Category
Diagnostics
Epidemiology
Subject
Testing
Public Health
Population
All
Clinical Setting
Community
Priority Level
Level 3 completed within 2-3 days
Cite As
Duncan, V. What sampling method is most appropriate for population testing? 2020 Apr 23; Document no.: LAB042201-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 14 p. (CEST evidence search report)
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Less detail
Document Type
Rapid Review
Review Code
LAB042201 RR
Question Submitted
April 22, 2020
Date Completed
April 23, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB042201 RR
Question Submitted
April 22, 2020
Date Completed
April 23, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
For COVID-19 there are no published data to identify optimal population sampling methods, however, a population-based sample in which testing is performed for both rt-PCR and serology might be recommended. There are also opportunities to examine innovative sampling strategies being used in pilot studies underway in other jurisdictions.
Category
Diagnostics
Epidemiology
Subject
Testing
Public Health
Population
All
Clinical Setting
Community
Priority Level
Level 3 completed within 2-3 days
Cite As
Vanstone, J; Reeder, B; Duncan, V. What sampling method is most appropriate for population testing? 2020 Apr 23; Document no.: LAB042201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 5 p. (CEST rapid review report)
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10 records – page 1 of 1.