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Accuracy of diagnostic tests for detection of infection with SARS CoV-2

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc76
Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
More detail
Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Key Findings
·      A wide range of tests are available for detection of viral RNA as well as serological and immunoassays for antibodies developed due to exposure to SARS CoV-2 in infected persons. Despite the emerging research, information about clinical validity of tests is limited. ·      Multiple factors affect test performance including the nature of the specific test, type of specimen and its quality, severity and duration of illness at the time of testing. These individual variations hamper assessment of diagnostic accuracy and suggest that a combination of tests on multiple types of specimens at serial time points might be needed to confirm a COVID 19 diagnosis. ·      Point of care tests are desirable and needed to scale up testing in low resource settings; however, tests are of variable quality and more research is needed before they can be relied on for clinical decision making.
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Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 4 completed within 1 week
Cite As
Williams-Roberts, H; Waldener, C. What is the accuracy of diagnostic tests for COVID-19 detection? 2020 May 12; Document no.: EPM051201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. (CEST rapid review report)
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Are less frequent (than daily) follow-up/monitoring used for close contacts in COVID or other communicable diseases?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc180
Document Type
Evidence Search Report
Review Code
PH092301-01 ESR
Question Submitted
September 23, 2020
Date Completed
September 25, 2020
Status
3. Completed
Research Team
Public Health
More detail
Document Type
Evidence Search Report
Review Code
PH092301-01 ESR
Question Submitted
September 23, 2020
Date Completed
September 25, 2020
Status
3. Completed
Research Team
Public Health
Category
Administration
Subject
Screening
Contact Tracing
Priority Level
Level 3 Two weeks (14 days)
Cite As
Dalidowicz, M; Miller, L. Are less frequent (than daily) follow-up/monitoring used for close contacts in COVID or other communicable diseases? 2020 Sep 25; Document no.: PH092301-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 27 p. (CEST evidence search report)
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Are less frequent (than daily) follow-up/monitoring used for close contacts in COVID or other communicable diseases?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc197
Document Type
Rapid Review
Review Code
PH092301 RR
Question Submitted
September 23, 2020
Date Completed
October 6, 2020
Status
3. Completed
Research Team
Public Health
More detail
Document Type
Rapid Review
Review Code
PH092301 RR
Question Submitted
September 23, 2020
Date Completed
October 6, 2020
Status
3. Completed
Research Team
Public Health
Key Findings
The evidence for alternative active monitoring schedules for confirmed cases of COVID-19 and their cases is limited
The prevailing consensus is that confirmed cases of COVID-19 and their high-risk close contacts should undergo active daily monitoring
When public health resources are limited, active monitoring programs should consider prioritizing vulnerable populations, incorporating passive monitoring practices and adopting virtual monitoring platforms
Category
Administration
Subject
Screening
Contact Tracing
Priority Level
Level 3 Two weeks (14 days)
Cite As
McLean, M; Groot, G; Dalidowicz, M; Miller, L. Are less frequent (than daily) follow-up/monitoring used in COVID or other communicable diseases? 2020 Oct 6; Document no.:PH092301 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 31 p. (CEST rapid review report)
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Are probiotics effective for prevention or therapy of respiratory tract infections in all ages?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc211
Document Type
Evidence Search Report
Review Code
EOC111201-01 ESR
Question Submitted
November 12, 2020
Date Completed
November 23, 2020
Status
3. Completed
Research Team
EOC
More detail
Document Type
Evidence Search Report
Review Code
EOC111201-01 ESR
Question Submitted
November 12, 2020
Date Completed
November 23, 2020
Status
3. Completed
Research Team
EOC
Category
Clinical Management
Subject
Treatment
Population
All
Priority Level
Level 4 Three weeks (21 days)
Cite As
Mueller, M; Young, C. Are probiotics effective for prevention or therapy of respiratory tract infections in all ages? 2020 Nov 23; Document no.: EOC111201-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 7 p. (CEST evidence search report)
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Are probiotics effective for prevention or therapy of respiratory tract infections in all ages?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc212
Document Type
Rapid Review
Review Code
EOC111201 RR
Question Submitted
November 12, 2020
Date Completed
November 25, 2020
Status
3. Completed
Research Team
EOC
More detail
Document Type
Rapid Review
Review Code
EOC111201 RR
Question Submitted
November 12, 2020
Date Completed
November 25, 2020
Status
3. Completed
Research Team
EOC
Key Findings
· Systematic reviews with pooled analysis found a statistical difference between probiotic and placebo groups in days of respiratory tract illness, number of antibiotic prescriptions and days of missed work/school · The evidence for the use of probiotics while statistically significant, is of low quality with high levels of heterogeneity · No significant difference in SAEs between groups, side effects of probiotic use mainly mild GI symptoms
Category
Clinical Management
Subject
Treatment
Population
All
Priority Level
Level 4 Three weeks (21 days)
Cite As
Badea, A; Groot, G; Mueller, M; Young, C. Are probiotics effective for prevention or therapy of respiratory tract infections in all ages? 2020 Nov 25; Document no.: EOC111201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 13 p. (CEST rapid review report)
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Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc250
Document Type
Evidence Search Report
Review Code
EOC012001-01 ESR
Question Submitted
January 19, 2021
Date Completed
January 25, 2021
Status
3. Completed
Research Team
EOC
More detail
Document Type
Evidence Search Report
Review Code
EOC012001-01 ESR
Question Submitted
January 19, 2021
Date Completed
January 25, 2021
Status
3. Completed
Research Team
EOC
Category
Administration
Clinical Management
Subject
Critical Care
Triage
Priority Level
Level 3 Two weeks (14 days)
Cite As
Dalidowicz, M; Fox, L. Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care? 2021 Jan 25; Document no.: EOC012001-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 87 p. (CEST evidence search report).
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Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc259
Document Type
Rapid Review
Review Code
EOC012001 RR
Question Submitted
January 19, 2021
Date Completed
February 4, 2021
Status
3. Completed
Research Team
EOC
More detail
Document Type
Rapid Review
Review Code
EOC012001 RR
Question Submitted
January 19, 2021
Date Completed
February 4, 2021
Status
3. Completed
Research Team
EOC
Key Findings
There is insufficient evidence to recommend a specific clinical prediction tool for COVID-19 patients at this time.
The 4C Mortality tool and associated risk calculator is likely the most validated prediction tool currently available.
Many tools exist and may be applied with caution, as they should be validated in the local context.
There are many patient factors included in different tools when calculating risk of disease severity.
Category
Administration
Clinical Management
Subject
Critical Care
Triage
Priority Level
Level 3 Two weeks (14 days)
Cite As
Vanstone, J; Groot, G; Dalidowicz, M; Fox, L. Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care? 2021 Feb 4; Document no.: EOC012001 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 15 p. (CEST rapid review report)
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Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc260
Document Type
Table
Review Code
EOC012001 RR Table
Question Submitted
January 19, 2021
Date Completed
February 4, 2021
Status
3. Completed
Research Team
EOC
More detail
Document Type
Table
Review Code
EOC012001 RR Table
Question Submitted
January 19, 2021
Date Completed
February 4, 2021
Status
3. Completed
Research Team
EOC
Category
Administration
Clinical Management
Subject
Critical Care
Triage
Priority Level
Level 3 Two weeks (14 days)
Cite As
Vanstone, J; Groot, G; Dalidowicz, M; Fox, L. Are there validated clinical prediction tools of which Covid-19 inpatients are most probable to require ICU level care? 2021 Feb 4; Document no.: EOC012001 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 15 p. (CEST table)
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At what level of surge capacity do quality of care indicators suffer?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc216
Document Type
Evidence Search Report
Review Code
CC120301-01 ESR
Question Submitted
December 3, 2020
Date Completed
December 4, 2020
Status
3. Completed
Research Team
Critical Care
More detail
Document Type
Evidence Search Report
Review Code
CC120301-01 ESR
Question Submitted
December 3, 2020
Date Completed
December 4, 2020
Status
3. Completed
Research Team
Critical Care
Category
Administration
Healthcare Services
Subject
Health Planning
Facilities
Triage
Population
All adults
Clinical Setting
ICU
Priority Level
Level 1 2-3 days
Cite As
Miller, L; Howell-Spooner, B. At what level of surge capacity do quality of care indicators suffer? 2020 Dec 4; Document no.: CC120301-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 50 p. (CEST evidence search report)
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At what level of surge capacity do quality of care indicators suffer?

https://covid19evidencereviews.saskhealthauthority.ca/en/permalink/coviddoc221
Document Type
Rapid Review
Review Code
CC120301 RR
Question Submitted
December 3, 2020
Date Completed
December 10, 2020
Status
3. Completed
Research Team
Critical Care
More detail
Document Type
Rapid Review
Review Code
CC120301 RR
Question Submitted
December 3, 2020
Date Completed
December 10, 2020
Status
3. Completed
Research Team
Critical Care
Key Findings
No studies directly evaluated the association between level of surge capacity and quality of care indicators for COVID-19 patients. However, in more broad studies, the findings suggest that mortality and other adverse events increase when the strain on the intensive care capacity increases.
A tiered staffing strategy is recommended to meet surge capacity needs in the ICU: High critical care nurse to patient ratios (1:1 or 1:2) are recommended to provide high quality patient care.
There is a lack of high-quality evidence to support ICU triage protocols tailored for patients with COVID-19. Nevertheless, the protocols must be flexible, adaptable according to the availability of local resources, and effective for inter-hospital patient transfer.
While the Crisis Standards of Care (CSC) guidelines (e.g., Saskatchewan’s Critical Care Resource Allocation Framework, published on September 2020) can be used to triage newly admitted COVID-19 patients requiring critical care, there is contradicting evidence about using the Sequential Organ Failure Assessment (SOFA) score for ICU triage of patients with COVID-19.
The literature suggests the use of mathematical modeling to support capacity planning (e.g., very low, low, medium, and high intensity patient surge response)
To relieve pressure from ICUs, other types of units (e.g., Step Down Unit [SDU] or Surge Clinic) can be implemented.
Category
Administration
Healthcare Services
Subject
Health Planning
Facilities
Triage
Population
All adults
Clinical Setting
ICU
Priority Level
Level 1 2-3 days
Cite As
Azizian, A; Valiani, S; Groot, G; Badea, A; Miller, L; Howell-Spooner, B. At what level of surge capacity do quality of care indicators suffer? 2020 Dec 10; Document no.: CC120301 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 17 p. (CEST rapid review report)
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279 records – page 1 of 28.