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Document Type
Rapid Review
Review Code
EOC081201 RR
Question Submitted
August 12, 2020
Date Completed
August 26, 2020
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC081201 RR
Question Submitted
August 12, 2020
Date Completed
August 26, 2020
Status
3. Completed
Research Team
EOC
Key Findings
· Potential impact on reproductive rate (R) of the seven “returning to school” scenarios that were modeled by SAGE exhibited an increase in R due to reopening of school. The scale of increase depended on current value of R within each community and mitigation plans within the community, especially the adherence to social distancing measures. · CDC recommended using additional indicators such as healthcare capacity, new cases, and percent of positive cases to decide school operations along with community spread levels: none-to-minimal, minimal-to-moderate, substantial-controlled, and substantial-uncontrolled. · Combination of strategies such as mask usage, physical distancing, hygiene measures, classroom cohorting, symptomatic screening, testing and tracing of students, staff and teachers along with low levels of community transmission can aid in maintaining low level of R. · Increasing testing and contract tracing can impede an epidemic rebound. · Intersectoral partnerships with local authorities, dedicated personnel (such as coordinators) for testing and tracing along with appropriate communication with parents, teachers and staff should be followed to open schools safely.
Category
Administration
Epidemiology
Subject
Reopening
Schools
Transmission
Public Health
Decision Making
Population
All Pediatrics
Priority Level
Level 4 completed within 1 week
Cite As
Pisolkar, V; McRae, D; Muhajarine, N; Dalidowicz, M; Ellsworth, C. What COVID community transmission indicators are used in school reopening plans? 2020 Aug 26; Document no.: EOC081201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 23 p. (CEST rapid review report)
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Document Type
Rapid Review
Review Code
EOC070901 RR
Question Submitted
July 9, 2020
Date Completed
August 17, 2020
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC070901 RR
Question Submitted
July 9, 2020
Date Completed
August 17, 2020
Status
3. Completed
Research Team
EOC
Key Findings
A number of jurisdictions have re-opened schools successfully without a spike in COVID-19 cases, eg. Japan, Germany, France, Finland, Denmark, Austria, Norway
Most school plans indicate that staff/students/visitors who are sick or have had exposure to COVID-19 in the past 14 days should not attend school, and those that become symptomatic at school should be isolated and removed from the premises as soon as possible, with thorough cleaning thereafter
In Alberta, if two or more members of a cohort are found to be COVID-19 positive, schools should follow the outbreak procedures which are under review until September
In Nova Scotia, one confirmed case of COVID-19 in a school would be considered an outbreak
In Germany, classmates and teachers of an infected student are sent home for two weeks but other classes continue
Taiwan (based on the H1N1 response) suspends the class which had a confirmed case identified, for 14 days. With two or more cases the whole school must close. When 1/3 of the schools in a district are closed, all schools in the district must close.
In Israel, schools closed after a single case was identified , and following mass outbreaks in schools at least 355 schools had closed with over 2,026 students and staff testing positive and over 28,000 students in quarantine due to possible exposure
Category
Infection Prevention and Control
Subject
Reopening
Closures
Schools
Public Health
Decision Making
Clinical Setting
Public Health
Priority Level
Level 5 completed within 2 weeks
Cite As
Badea, A; Muhajarine, N; Reeder, B; Miller, L; Mueller, M. What is the evidence and rationale describing the key public health principles to consider for school re-openings and precautions regarding school closures during COVID-19? 2020 Aug 17; Document no.: EOC070901 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 22 p. (CEST rapid review report)
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Document Type
Supplementary
Review Code
EOC081401 SR
Question Submitted
August 14, 2020
Date Completed
August 14, 2020
Status
5. Updated review
Research Team
EOC
Document Type
Supplementary
Review Code
EOC081401 SR
Question Submitted
August 14, 2020
Date Completed
August 14, 2020
Status
5. Updated review
Research Team
EOC
Category
Administration
Infection Prevention and Control
Subject
Saskatchewan
Reopening
Schools
Priority Level
Level 4 completed within 1 week
Cite As
Muhajarine N, McRae D, Pisolkar V, et al. Saskatchewan’s school re-opening plan in comparison to other provincial plans and federal recommendations. 2020 Aug 14; Document no.: EOC081401 SR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 34 p. (CEST Summary Report)
Review History
EOC081401 RR: August 24, 2020
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Document Type
Evidence Search Report
Review Code
EOC081201-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC081201-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
Category
Administration
Epidemiology
Subject
Reopening
Schools
Transmission
Public Health
Decision Making
Population
All Pediatrics
Priority Level
Level 4 completed within 1 week
Cite As
Dalidowicz, M; Ellsworth, C. What COVID-19 community transmission indicators are used in school reopening plans? 2020 Aug 12; Document no.: EOC081201-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 12 p. (CEST evidence search report)
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Document Type
Evidence Search Report
Review Code
EOC070901v2-01 ESR
Question Submitted
July 9, 2020
Date Completed
August 6, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC070901v2-01 ESR
Question Submitted
July 9, 2020
Date Completed
August 6, 2020
Status
3. Completed
Research Team
EOC
Category
Infection Prevention and Control
Subject
Reopening
Closures
Schools
Public Health
Decision Making
Clinical Setting
Public Health
Priority Level
Level 5 completed within 2 weeks
Cite As
Miller, L; Mueller, M. What is the evidence and rationale describing the key public health principles to consider for school re-openings and precautions regarding school closures during COVID-19? 2020 Aug 6; Document no.: EOC070901v2-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 25 p. (CEST evidence search report)
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EOC070901v2-01 ESR

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Document Type
Rapid Review
Review Code
EPM072101 RR
Question Submitted
July 21, 2020
Date Completed
July 23, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Document Type
Rapid Review
Review Code
EPM072101 RR
Question Submitted
July 21, 2020
Date Completed
July 23, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Key Findings
· Diagnostic accuracy of tests for SARS CoV-2 varies based on the type of test, target antigen, type of sample and time of testing. · There is heterogeneity in clinical performance of rapid antigen tests; however, clinical sensitivity is lower than amplification-based assays. · Information is limited about test strategies that combine multiple approaches (e.g. molecular and serological methods) but may add value by increasing sensitivity and specificity.
Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 2 completed within 8 hours
Cite As
Williams-Roberts, H; Waldner, C; Dalidowicz, M; Howell-Spooner, B. What is the accuracy of diagnostic tests for the detection of SARS-CoV-2? 2020 Jul 23; Document no.: EPM072101 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 13 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
EPM072101-01 ESR
Question Submitted
July 21, 2020
Date Completed
July 21, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Document Type
Evidence Search Report
Review Code
EPM072101-01 ESR
Question Submitted
July 21, 2020
Date Completed
July 21, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 2 completed within 8 hours
Cite As
Howell-Spooner, B; Dalidowicz, M. What is the accuracy of diagnostic tests for the detection of SARS-CoV-2? 2020 Jul 21; Document no.: EPM072101-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 42 p. (CEST evidence search report)
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Document Type
Table
Review Code
EPM072101 RR Table
Question Submitted
July 21, 2020
Date Completed
July 21, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Document Type
Table
Review Code
EPM072101 RR Table
Question Submitted
July 21, 2020
Date Completed
July 21, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 2 completed within 8 hours
Cite As
Williams-Roberts, H; Waldner, C; Dalidowicz, M; Howell-Spooner, B. What is the accuracy of diagnostic tests for the detection of SARS-CoV-2? 2020 Jul 23; Document no.: EPM072101 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. (CEST table)
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Document Type
Evidence Search Report
Review Code
EOC070901-01 ESR
Question Submitted
July 9, 2020
Date Completed
July 13, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC070901-01 ESR
Question Submitted
July 9, 2020
Date Completed
July 13, 2020
Status
3. Completed
Research Team
EOC
Category
Infection Prevention and Control
Subject
Reopening
Closures
Schools
Public Health
Decision Making
Clinical Setting
Public Health
Priority Level
Level 5 completed within 2 weeks
Cite As
Miller, L; Mueller, M. What is the evidence and rationale describing the key public health principles to consider for school re-openings and precautions regarding school closures during COVID-19? 2020 Jul 13; Document no.: EOC070901-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 22 p. (CEST evidence search report)
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Document Type
Evidence Search Report
Review Code
LAB040802v3-01 ESR
Question Submitted
April 8, 2020
Date Completed
June 2, 2020
Status
5. Updated review
Research Team
Laboratory
Document Type
Evidence Search Report
Review Code
LAB040802v3-01 ESR
Question Submitted
April 8, 2020
Date Completed
June 2, 2020
Status
5. Updated review
Research Team
Laboratory
Category
Diagnostics
Administration
Subject
Testing
Serology
Polymerase Chain Reaction
Health Personnel
Population
All
Priority Level
Level 2 completed within 8 hours
Cite As
Duncan, V; Howell-Spooner, B. What proportion of healthcare workers are rt-PCR positive and IgM or IgG positive? 2020 Jun 2; Document no.: LAB040802v3-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 22 p. (CEST evidence search report)
Review History
LAB040802v2 RR: May 19, 2020
LAB040802 RR: April 9, 2020
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LAB040802v3-01 ESR

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Document Type
Rapid Review
Review Code
LAB040802v3 RR
Question Submitted
April 8, 2020
Date Completed
June 2, 2020
Status
5. Updated review
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB040802v3 RR
Question Submitted
April 8, 2020
Date Completed
June 2, 2020
Status
5. Updated review
Research Team
Laboratory
Key Findings
Several references provide estimates of the proportion of HCW infected with SARS-CoV2 that range from 0.9% -20%. A recent review from Alberta Health Services that examined the COVID-19 rt-PCR test results among HCW indicates that in that province 2.4% of physicians and 0.9% of non-MD HCW who were tested were positive for SARS-CoV-2 compared to 3.5% of the general population.
In the studies reviewed, the majority of cases are confirmed by RT-PCR, while only one reference also used serology testing.
Category
Diagnostics
Administration
Subject
Testing
Serology
Polymerase Chain Reaction
Health Personnel
Population
All
Priority Level
Level 2 completed within 8 hours
Cite As
Vanstone, J; Reeder, B; Duncan, V; Howell-Spooner, B. What proportion of healthcare workers are rt-PCR positive and IgM or IgG positive? 2020 Jun 2; Document no.: LAB040802v3 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 10 p. (CEST rapid review report)
Review History
LAB040802v2 RR: May 19, 2020
LAB040802 RR: April 9, 2020
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Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Key Findings
·      A wide range of tests are available for detection of viral RNA as well as serological and immunoassays for antibodies developed due to exposure to SARS CoV-2 in infected persons. Despite the emerging research, information about clinical validity of tests is limited. ·      Multiple factors affect test performance including the nature of the specific test, type of specimen and its quality, severity and duration of illness at the time of testing. These individual variations hamper assessment of diagnostic accuracy and suggest that a combination of tests on multiple types of specimens at serial time points might be needed to confirm a COVID 19 diagnosis. ·      Point of care tests are desirable and needed to scale up testing in low resource settings; however, tests are of variable quality and more research is needed before they can be relied on for clinical decision making.
Notes
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Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 4 completed within 1 week
Cite As
Williams-Roberts, H; Waldener, C. What is the accuracy of diagnostic tests for COVID-19 detection? 2020 May 12; Document no.: EPM051201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. (CEST rapid review report)
Similar Reviews
PH042401 RR
LAB041401 RR
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EPM051201 RR

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Document Type
Evidence Search Report
Review Code
EOC042202-02 ESR
Question Submitted
April 22, 2020
Date Completed
May 6, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC042202-02 ESR
Question Submitted
April 22, 2020
Date Completed
May 6, 2020
Status
3. Completed
Research Team
EOC
Category
Administration
Subject
Closures
Reopening
Health Planning
Outcome Assessment
Risk
Population
All
Priority Level
Level 4 completed within 1 week
Cite As
Miller, L; Young, C. What is the best evidence to guide the sequence or priority of re-opening each type of healthcare service and how have the closures impacted patients? 2020 May 6; Document no.: EOC042202-02 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 31 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
EOC042202 RR
Question Submitted
April 22, 2020
Date Completed
April 27, 2020
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC042202 RR
Question Submitted
April 22, 2020
Date Completed
April 27, 2020
Status
3. Completed
Research Team
EOC
Key Findings
There are no published or grey literature that directly address the review questions · A number of principle based guidelines/recommendations/criteria are available and reviewed. It appears that the WHO interim guidance "Considerations in adjusting public health and social measures in the context of COVID-19" is the best piece of evidence available right now. It is included in the reference list below.
Notes
INTERIM Rapid Review
Category
Administration
Subject
Closures
Reopening
Health Planning
Outcome Assessment
Risk
Population
All
Priority Level
Level 4 completed within 1 week
Cite As
Badea, A; Reeder, B; Groot, G; Miller, L; Young, C. What is the best evidence to guide the sequence or priority of re-opening each type of healthcare service and how have the closures impacted patients? 2020 Apr 24; Document no.: EOC042202 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 11 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
EOC042202-01 ESR
Question Submitted
April 22, 2020
Date Completed
April 23, 2020
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC042202-01 ESR
Question Submitted
April 22, 2020
Date Completed
April 23, 2020
Status
3. Completed
Research Team
EOC
Category
Administration
Subject
Closures
Reopening
Health Planning
Outcome Assessment
Risk
Population
All
Priority Level
Level 4 completed within 1 week
Cite As
Miller, L; Young, C. What is the best evidence to guide the sequence or priority of re-opening each type of healthcare service and how have the closures impacted patients? 2020 Apr 23; Document no.: EOC042202-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 5 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
LAB041501 RR
Question Submitted
April 15, 2020
Date Completed
April 17, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB041501 RR
Question Submitted
April 15, 2020
Date Completed
April 17, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
Seroconversion occurs in majority of COVID-19 patients from the second week following symptomonseton.
Between 7.8 -43.6% of suspect cases and 4.7% of asymptomatic individuals with negative nucleic acid test (rt-PCR) test positive for antibodies against SARS-CoV-2.
An increase in antibody titrescorrelates with a neutralizing antibody response and positive recovery of COVID-19 patients with mild to moderate symptoms.
Although higher antibody titreand more robust antibody response are observed in severe and critically ill patients, those antibodies may not effectively clear virus and higher antibody levels may be associated with a worse clinical progress.
Category
Clinical Presentation
Subject
Antibodies
Natural History
Serology
Priority Level
Level 2 completed within 8 hours
Cite As
Wang, H; Reeder, B; Howell-Spooner, B. How well does the presence and level of antibodies predict the clinical course of disease? 2020 Apr 17; Document no.: LAB041501 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 5 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
LAB041501-01 ESR
Question Submitted
April 15, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Evidence Search Report
Review Code
LAB041501-01 ESR
Question Submitted
April 15, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Category
Clinical Presentation
Subject
Antibodies
Natural History
Serology
Priority Level
Level 2 completed within 8 hours
Cite As
Howell-Spooner, B. How well does the presence and level of antibodies predict the clinical course of disease? 2020 Apr 15; Document no.: LAB041501-01 ESR In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 22 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
LAB041402 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB041402 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
The majority of patients (>50%) appear to seroconvert between 8-14 days following the onset of symptoms.
Nearly all patients (>80%) seroconvert >15 days following the onset of symptoms.
The IgM response is detected earlier (median 12 days) than the IgG response (median 14 days).
Seroconversion appears to follow clinical recovery in most cases.
Category
Clinical Presentation
Subject
Antibodies
Natural History
Serology
Population
All
Priority Level
Level 2 completed within 8 hours
Cite As
Vanstone, J; Reeder, B; Duncan, V. At what time in the disease timeline of COVID-19 do antibodies develop? 2020 Apr 15; Document no.: LAB041402 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 4 p. (CEST rapid review report)
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Document Type
Rapid Review
Review Code
LAB041401 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Rapid Review
Review Code
LAB041401 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
Moderate to strong grade evidence show the overall sensitivityrangeof IgM, IgG, and combined IgM/IgG are 48.1% to 94.1%, 64.7% to 100%, 83% to 100%, respectively.
IgM/IgG combined assay, with the posterior probability of 99.15%, has greater accuracyand sensitivity than a single IgM or IgG test.
The sensitivity of antibody tests is extremely low (~ 11.1%) in the first week following the onsetof symptoms but increasesrapidlyduring the second week.
IgG and IgM titers in patients with severe disease arehigher than those in the non-severe patients.
Antibody testsmay detect the presence of COVID-19 in asymptomatic individuals with negative rt-PCRresults.
Category
Clinical Presentation
Subject
Testing
Serology
Antibodies
Priority Level
Level 2 completed within 8 hours
Cite As
Wang, H; Reeder, B; Howell-Spooner, B. How well does the presence and level of antibodies predict the presence or absence of the disease? 2020 Apr 15; Document no.: LAB041401 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 9 p. (CEST rapid review report)
Similar Reviews
PH042401 RR
EPM051201 RR
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Less detail
Document Type
Evidence Search Report
Review Code
LAB041401-01 ESR
Question Submitted
April 14, 2020
Date Completed
April 14, 2020
Status
3. Completed
Research Team
Laboratory
Document Type
Evidence Search Report
Review Code
LAB041401-01 ESR
Question Submitted
April 14, 2020
Date Completed
April 14, 2020
Status
3. Completed
Research Team
Laboratory
Category
Clinical Presentation
Subject
Testing
Antibodies
Serology
Priority Level
Level 2 completed within 8 hours
Cite As
Howell-Spooner, B. How well does the presence and level of antibodies predict the presence or absence of the disease? 2020 Apr 14; Document no.: LAB041401-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 20 p. (CEST evidence search report)
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23 records – page 1 of 2.