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Document Type
Table
Review Code
INF031801v019 RR Table
Question Submitted
March 18, 2021
Date Completed
December 26, 2021
Status
5. Updated review
Research Team
Infectious Disease
Document Type
Table
Review Code
INF031801v019 RR Table
Question Submitted
March 18, 2021
Date Completed
December 26, 2021
Status
5. Updated review
Research Team
Infectious Disease
Category
Epidemiology
Infection Prevention and Control
Subject
Vaccines
Immunity
Infection Prevention and Control
Clinical Presentation
Population
All
Clinical Setting
Community
ICU
Medicine Unit
Primary care
Public Health
Priority Level
Level 3 Two weeks (14 days)
Cite As
Jagwani, M; Lee, S; Shumilak, G; Reeder, B; Groot, G; Hernandez, L; Howell-Spooner, B; Miller, L. How effective are COVID-19 vaccines? 2021 Dec 26; Document no.: INF031801v019 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. (CEST Table)
Similar Reviews
EOC011901 RR
EOC031001 RR
Review History
INF031801v17 RR: November 23, 2021
INF031801v16 RR: November 12, 2021
INF031801v15 RR: October 28, 2021
INF031801v014 RR: October 16, 2021
INF031801v013 RR: September 24, 2021
INF031801v012 RR: September 10, 2021
INF031801v010 RR: August 25, 2021
INF031801v9 RR: August 23, 2021
INF031801v8 RR: August 9, 2021
INF031801v7 RR: July 20, 2021
INF031801v6 RR: July 2, 2021
INF031801v5 RR: June 22, 2021
INF031801v4 RR: June 3, 2021
INF031801v3 RR: May 24, 2021
INF031801v2 RR: May 14, 2021
INF031801 RR: March 31, 2021
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INF031801v019 RR Table

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Document Type
Evidence Search Report
Review Code
INF031801v020 ESR
Question Submitted
March 18, 2021
Date Completed
January 14, 2022
Status
5. Updated review
Research Team
Infectious Disease
Document Type
Evidence Search Report
Review Code
INF031801v020 ESR
Question Submitted
March 18, 2021
Date Completed
January 14, 2022
Status
5. Updated review
Research Team
Infectious Disease
Category
Epidemiology
Infection Prevention and Control
Subject
Vaccines
Infection Prevention and Control
Clinical Presentation
Immunity
Population
All
Clinical Setting
Community
ICU
Medicine Unit
Primary care
Public Health
Priority Level
Level 3 Two weeks (14 days)
Cite As
Miller, L., Howell-Spooner, B. How effective are COVID-19 vaccines? 2022 Jan 14, Document no.: INF031801v020 ESR . In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 9 p. (CEST evidence search report).
Similar Reviews
EOC220304
Review History
INF031801v17 RR: November 23, 2021
INF031801v16 RR: November 12, 2021
INF031801v15 RR: October 28, 2021
INF031801v014 RR: October 16, 2021
INF031801v013 RR: September 24, 2021
INF031801v012 RR: September 10, 2021
INF031801v010 RR: August 25, 2021
INF031801v9 RR: August 23, 2021
INF031801v8 RR: August 9, 2021
INF031801v7 RR: July 20, 2021
INF031801v6 RR: July 2, 2021
INF031801v5 RR: June 22, 2021
INF031801v4 RR: June 3, 2021
INF031801v3 RR: May 24, 2021
INF031801v2 RR: May 14, 2021
INF031801 RR: March 31, 2021
Related Documents
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Less detail
Document Type
Rapid Review
Review Code
INF031801v019 RR
Question Submitted
March 18, 2021
Date Completed
December 26, 2021
Status
5. Updated review
Research Team
Infectious Disease
Document Type
Rapid Review
Review Code
INF031801v019 RR
Question Submitted
March 18, 2021
Date Completed
December 26, 2021
Status
5. Updated review
Research Team
Infectious Disease
Updated Key Findings
December 14, 2021
Ontario Immunization Advisory Committee recommended that if an 11 and 12-year-old child is inadvertently given a second dose of the Pfizer-BioNTech vaccine that is not authorized for their age, the dose should be considered valid and the series complete.
National Advisory Committee on Immunization (NACI) recommends that a booster dose of an authorized mRNA COVID-19 vaccine should be offered to vulnerable population and > 50 years old, =6 months after completion of a primary COVID-19 vaccine series.
Australian Technical Advisory Group on Immunization (ATAGI) recommends COVID-19 booster vaccination with either Pfizer (Comirnaty) or Moderna (Spikevax), which are considered equally acceptable, for anyone aged 18 and older who completed their primary course of COVID-19 vaccination 5 or more months ago.
On December 8th, 2021 in a press release by Pfizer-BioNTech said that preliminary laboratory studies demonstrate that three doses of the Pfizer-BioNTech COVID-19 vaccine neutralize the Omicron variant while two doses show significantly reduced neutralization titers. Data indicate that a third dose of BNT162b2 increases the neutralizing antibody titers by 25-fold compared to two doses.
Key Findings
December 3, 2021
The Therapeutic Goods Administration (TGA) has granted provisional approval to Moderna for the use of its vaccine in children (two 10µg doses) and as booster shot for adults (one 30µg dose) in preparation for the recent emergence of the Omicron variant. This is in addition to Pfizer, which was also recently approved.
The National Advisory Committee on Immunization (NACI) recommends that a complete series with the Pfizer-BioNTech COVID-19 vaccine (10 mcg) may be offered to children 5-11 years of age who do not have contraindications to the vaccine, with a dosing interval of at least 8 weeks between the first and second dose.
NNACI also recommends that children aged 5-11 years with a history of previous SARS-CoV-2 infection should be considered no longer infectious and symptoms of an acute illness should be completely resolved prior to vaccination.
Health Canada has authorized Moderna's COVID-19 vaccine (also known as Spikevax) to be used as a booster shot, using a half-dose of the vaccine.
Category
Epidemiology
Infection Prevention and Control
Subject
Vaccines
Immunity
Infection Prevention and Control
Clinical Presentation
Population
All
Clinical Setting
Community
ICU
Medicine Unit
Primary care
Public Health
Priority Level
Level 3 Two weeks (14 days)
Cite As
Jagwani, M; Lee, S; Shumilak, G; Reeder, B; Groot, G; Hernandez, L; Howell-Spooner, B; Miller, L. How effective are COVID-19 vaccines? 2021 Dec 26. Document no.: INF031801v019 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 93 p. (CEST rapid review report)
Review History
INF031801v17 RR: November 23, 2021
INF031801v16 RR: November 12, 2021
INF031801v15 RR: October 28, 2021
INF031801v014 RR: October 16, 2021
INF031801v013 RR: September 24, 2021
INF031801v012 RR: September 10, 2021
INF031801v010 RR: August 25, 2021
INF031801v9 RR: August 23, 2021
INF031801v8 RR: August 9, 2021
INF031801v7 RR: July 20, 2021
INF031801v6 RR: July 2, 2021
INF031801v5 RR: June 22, 2021
INF031801v4 RR: June 3, 2021
INF031801v3 RR: May 24, 2021
INF031801v2 RR: May 14, 2021
INF031801 RR: March 31, 2021
Related Documents
Documents
Less detail
Document Type
Evidence Search Report
Review Code
EOC220502 ESR
Question Submitted
May 3, 2022
Date Completed
May 9, 2022
Status
3. Completed
Research Team
EOC
male and 21 were female. The clinical presentation was highly reproducible with chilblain-like lesions
Document Type
Evidence Search Report
Review Code
EOC220502 ESR
Question Submitted
May 3, 2022
Date Completed
May 9, 2022
Status
3. Completed
Research Team
EOC
Category
Clinical Presentation
Subject
Clinical Presentation
Priority Level
Level 3 Two weeks (14 days)
Cite As
Dalidowicz, M; Miller, L. Is there any association or links between COVID and interferonopathy or polymyositis? 2022 May 09, Document no.: EOC220502 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 9 p. (CEST evidence search report).
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Documents
Less detail
Document Type
Table
Review Code
EOC220502 RR Table
Question Submitted
May 3, 2022
Date Completed
May 11, 2022
Status
3. Completed
Research Team
EOC
Document Type
Table
Review Code
EOC220502 RR Table
Question Submitted
May 3, 2022
Date Completed
May 11, 2022
Status
3. Completed
Research Team
EOC
Category
Clinical Presentation
Subject
Clinical Presentation
Priority Level
Level 3 Two weeks (14 days)
Cite As
Badea, A; Groot, G; Reeder, B; Dalidowicz, M; Miller, L. Is there any association or links between COVID and interferonopathy or polymyositis? 2022 May 11, Document no.: EOC220502 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. (CEST table).
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EOC220502 RR Table

Download File
Less detail
Document Type
Rapid Review
Review Code
EOC220502 RR
Question Submitted
May 3, 2022
Date Completed
May 11, 2022
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC220502 RR
Question Submitted
May 3, 2022
Date Completed
May 11, 2022
Status
3. Completed
Research Team
EOC
Key Findings
Several cases of COVID-19 linked myositis have been reported in the literature, most occurring in adult males
COVID-linked myositis has varied presentations; blood panels or imaging may appear normal
Similarity between COVID-19 linked myositis and anti-melanoma differentiation associated gene 5 (MDA5)-positive myositis may represent an avenue for exploring treatment strategies
Described cases involve treatment with steroids and anti-inflammatory drugs during in-hospital stay
Most cases described experience a prolonged recovery of weeks to months, however due to short post-discharge follow-up periods, long-term recovery is yet unknown
Category
Clinical Presentation
Subject
Clinical Presentation
Priority Level
Level 3 Two weeks (14 days)
Cite As
Badea, A; Groot, G; Reeder, B; Dalidowicz, M; Miller, L. Is there any association or links between COVID and interferonopathy or polymyositis? 2022 May 11, Document no.: EOC220502 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 7 p. (CEST rapid review report).
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Less detail
Document Type
Evidence Search Report
Review Code
EOC021901v2 ESR
Question Submitted
February 19, 2021
Date Completed
October 21, 2021
Status
5. Updated review
Research Team
EOC
by the World Health Organization (WHO). The clinical presentation of SARS-CoV-2 infection depends
Document Type
Evidence Search Report
Review Code
EOC021901v2 ESR
Question Submitted
February 19, 2021
Date Completed
October 21, 2021
Status
5. Updated review
Research Team
EOC
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs to? 2021 Oct 21, Document no.: EOC021901v2 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 70 p. (CEST rapid review report).
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Documents
Less detail
Document Type
Table
Review Code
EOC021901v2 RR Table
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Document Type
Table
Review Code
EOC021901v2 RR Table
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Williams-Roberts, H; Groot, G; Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs? 2021 Oct 29. Document no.: EOC021901v2 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. (CEST Table).
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EOC021901v2 RR Table

Download File
Less detail
Document Type
Rapid Review
Review Code
EOC021901v2 RR
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC021901v2 RR
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Updated Key Findings
October 29, 2021
In October, WHO released a consensus definition of post COVID-19 condition that includes 12 domains. This development should lead to better standardization of reporting and contribute to more precise prevalence estimates and better understanding of associated risk factors.
The effects of Variants of Concern (VoC) and COVID vaccination on progression of Long COVID symptoms remains unclear.
Risk factors for developing Long COVID symptoms were similar but limited evidence suggests that pre-pandemic psychological distress and poor general health were associated with developing persistent symptoms. Evidence is too limited to determine whether vaccination reduces the risk of developing Long COVID among persons with breakthrough infections.
Given the protean manifestations of Long COVID symptoms, the underlying causes are likely multifactorial; however, strong evidence to substantiate the theories of causation remains limited.
Research related to longer-term consequences of SARS CoV-2 infections in pediatric populations is growing but remains limited.
Key Findings
March 15, 2021
There is a lack of consensus around the clinical definition of Long COVID which in turn causes challenges with understanding the incidence and prevalence as well as the potential impact for the health care system
Information about the natural history of Long COVID is incomplete but limited evidence suggests that the immune response trajectories differ for those with few or no symptoms compared to those with severe disease. Individuals with severe disease are more likely to exhibit immunological marker abnormalities but anyone can experience functional limitations.
The mechanisms underlying the development of persistent symptoms in Long COVID remain an enigma. Despite multiple theories, there is little empirical evidence for specific immunological and or biochemical abnormalities in samples of individuals with symptoms consistent with Long COVID.
Risk factors for Long COVID include female gender, older age, higher body mass index, pre-existing asthma and the number of symptoms.
Few studies explored the short-term impact of Long COVID on health care utilization patterns and found a higher impact for those with severe disease compared with mild disease.
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Williams-Roberts, H; Groot, G; Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs? 2021 Oct 29. Document no.: EOC021901v2 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 14 p. (CEST rapid review report).
Related Documents
Documents
Less detail
Document Type
Rapid Review
Review Code
EOC220303 RR
Question Submitted
March 3, 2022
Date Completed
June 30, 2022
Status
3. Completed
Research Team
EOC
Document Type
Rapid Review
Review Code
EOC220303 RR
Question Submitted
March 3, 2022
Date Completed
June 30, 2022
Status
3. Completed
Research Team
EOC
Key Findings
Telemedicine and other technologies are being adopted and tested to facilitate appointments over video/audio call, as well as to deliver various rehabilitation programs.
Telemedicine may be a solution that increases specialist and primary care providers’ capacity to serve more patients.
Many studies focusing on rehabilitation for certain post COVID-19 conditions, such as shortness of breath (dyspnea) and fatigue, emphasize physiotherapy as a key aspect in recovery efforts.
Most studies and reviews endorse adopting multi-disciplinary care pathways to address the broad range of post COVID-19 symptoms.
Alternate treatment methods, such as singing and vocal therapy, are being studied with preliminary data supporting these as potentially effective interventions.
Attentive rehabilitation programs with frequent follow-ups from facilitators addressing physical and psychological barriers to recovery often result in improved health related quality of life in patients.
Although many (?) care pathways have yet to be formally evaluated, many resources and guidance documents for care providers and patients are available online from reputable organizations, such as the WHO, and are frequently updated with new information.
Social media and other digital media sources have caused confusion amongst much of the general public and have greatly contributed to the sharing of misinformation about COVID-19 and post conditions, as well as vaccination safety and efficacy.
Category
Clinical Management
Healthcare Services
Subject
Long Covid
Clinical Presentation
Decision Making
Health Planning
Population
All
Priority Level
Level 3 Two weeks (14 days)
Cite As
Hammond, B; Dalidowicz, M; Miller L; Groot, G; Reeder, B. Response to Long COVID: What are the Programs or accommodations to current frameworks? 2022 Jun 30. Document no.: EOC220303 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 21 p. (CEST rapid review report).
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24 records – page 1 of 3.