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Document Type
Evidence Search Report
Review Code
EOC021901v2 ESR
Question Submitted
February 19, 2021
Date Completed
October 21, 2021
Status
5. Updated review
Research Team
EOC
-19 Evidence Support Team EVIDENCE SEARCH REPORT Review Question: Long COVID: What does it mean
Document Type
Evidence Search Report
Review Code
EOC021901v2 ESR
Question Submitted
February 19, 2021
Date Completed
October 21, 2021
Status
5. Updated review
Research Team
EOC
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs to? 2021 Oct 21, Document no.: EOC021901v2 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 70 p. (CEST rapid review report).
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Document Type
Table
Review Code
EOC021901v2 RR Table
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
: Long COVID: What does it mean for the healthcare system and programs to deal with it? Review Code
Document Type
Table
Review Code
EOC021901v2 RR Table
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Williams-Roberts, H; Groot, G; Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs? 2021 Oct 29. Document no.: EOC021901v2 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. (CEST Table).
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EOC021901v2 RR Table

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Document Type
Rapid Review
Review Code
EOC021901v2 RR
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Support Team RAPID REVIEW REPORT Long COVID: What does it mean for the healthcare system and programs
Document Type
Rapid Review
Review Code
EOC021901v2 RR
Question Submitted
February 19, 2021
Date Completed
October 29, 2021
Status
5. Updated review
Research Team
EOC
Updated Key Findings
October 29, 2021
In October, WHO released a consensus definition of post COVID-19 condition that includes 12 domains. This development should lead to better standardization of reporting and contribute to more precise prevalence estimates and better understanding of associated risk factors.
The effects of Variants of Concern (VoC) and COVID vaccination on progression of Long COVID symptoms remains unclear.
Risk factors for developing Long COVID symptoms were similar but limited evidence suggests that pre-pandemic psychological distress and poor general health were associated with developing persistent symptoms. Evidence is too limited to determine whether vaccination reduces the risk of developing Long COVID among persons with breakthrough infections.
Given the protean manifestations of Long COVID symptoms, the underlying causes are likely multifactorial; however, strong evidence to substantiate the theories of causation remains limited.
Research related to longer-term consequences of SARS CoV-2 infections in pediatric populations is growing but remains limited.
Key Findings
March 15, 2021
There is a lack of consensus around the clinical definition of Long COVID which in turn causes challenges with understanding the incidence and prevalence as well as the potential impact for the health care system
Information about the natural history of Long COVID is incomplete but limited evidence suggests that the immune response trajectories differ for those with few or no symptoms compared to those with severe disease. Individuals with severe disease are more likely to exhibit immunological marker abnormalities but anyone can experience functional limitations.
The mechanisms underlying the development of persistent symptoms in Long COVID remain an enigma. Despite multiple theories, there is little empirical evidence for specific immunological and or biochemical abnormalities in samples of individuals with symptoms consistent with Long COVID.
Risk factors for Long COVID include female gender, older age, higher body mass index, pre-existing asthma and the number of symptoms.
Few studies explored the short-term impact of Long COVID on health care utilization patterns and found a higher impact for those with severe disease compared with mild disease.
Category
Healthcare Services
Clinical Presentation
Subject
Long Covid
Clinical Presentation
Health Planning
Symptoms
Population
All
Clinical Setting
Ambulatory
Long Term Care
Primary care
Priority Level
Level 5 Four weeks+ (28 days+)
Cite As
Williams-Roberts, H; Groot, G; Mueller, M; Dalidowicz, M. Long COVID: What does it mean for the healthcare system and programs? 2021 Oct 29. Document no.: EOC021901v2 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 14 p. (CEST rapid review report).
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Document Type
Evidence Search Report
Review Code
EPM210602 ESR
Question Submitted
June 22, 2021
Date Completed
June 25, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
this information to make more informed predictions about long-covid Review Code: EPM210602 ESR Complete Date
Document Type
Evidence Search Report
Review Code
EPM210602 ESR
Question Submitted
June 22, 2021
Date Completed
June 25, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
Category
Clinical Presentation
Epidemiology
Subject
Long Covid
Health Planning
Clinical Presentation
Population
All
Clinical Setting
Ambulatory
Community
Emergency
ICU
Long Term Care
Medicine Unit
Primary care
Public Health
Priority Level
Level 1 2-3 days
Cite As
Howell-Spooner, B; Ellsworth, C. What are long COVID's demands on the healthcare system, and it? 2021 Jun 25, Document no.: EPM210602 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 64 p. (CEST rapid review report).
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Document Type
Table
Review Code
EPM210602 RR Table
Question Submitted
June 22, 2021
Date Completed
July 12, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
Findings Definition of Long COVID Median age(IQR) Gender (n,%) No of patients Outcomes assessed Outcome
Document Type
Table
Review Code
EPM210602 RR Table
Question Submitted
June 22, 2021
Date Completed
July 12, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
Category
Clinical Presentation
Epidemiology
Subject
Long Covid
Health Planning
Clinical Presentation
Population
All
Clinical Setting
Ambulatory
Community
Emergency
ICU
Long Term Care
Medicine Unit
Primary care
Public Health
Priority Level
Level 1 2-3 days
Cite As
McLean, M; Williams-Roberts, H; Reeder, B; Howell-Spooner, B; Ellsworth, C. What are long COVID's demands on the healthcare system, and its severity of the illness? 2021 Jul 12, Document no.: EPM210602 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. (CEST table).
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EPM210602 RR Table

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Document Type
Rapid Review
Review Code
EPM210602 RR
Question Submitted
June 22, 2021
Date Completed
July 12, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
. Key Findings  Long COVID-19 is likely to increase healthcare demands across the health system
Document Type
Rapid Review
Review Code
EPM210602 RR
Question Submitted
June 22, 2021
Date Completed
July 12, 2021
Status
4. Update in progress
Research Team
Epidemiology & Modelling
Key Findings
Long COVID-19 is likely to increase healthcare demands across the health system, including emergency departments, hospital admissions, primary care visits, specialists appointments, and home care and rehabilitation services.
The clinical care burden of long COVID-19 is the greatest in the first 3 months after testing and is likely to place the greatest demand on primary care services.
Patients with severe COVID-19 illness are more likely to place longer-term demands (4-6 months) on specialist care due to respiratory, circulatory, endocrine, metabolic, psychiatric and unspecified conditions.
Category
Clinical Presentation
Epidemiology
Subject
Long Covid
Health Planning
Clinical Presentation
Population
All
Clinical Setting
Ambulatory
Community
Emergency
ICU
Long Term Care
Medicine Unit
Primary care
Public Health
Priority Level
Level 1 2-3 days
Cite As
McLean, M; Williams-Roberts, H; Reeder, B; Howell-Spooner, B; Ellsworth, C. What are long COVID's demands on the healthcare system, and its severity of the illness? 2021 Jul 12, Document no.: EPM210602 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 23 p. (CEST rapid review report).
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Document Type
Evidence Search Report
Review Code
EOC220201 ESR
Question Submitted
February 7, 2022
Date Completed
February 10, 2022
Status
3. Completed
Research Team
EOC
Document Type
Evidence Search Report
Review Code
EOC220201 ESR
Question Submitted
February 7, 2022
Date Completed
February 10, 2022
Status
3. Completed
Research Team
EOC
Category
Healthcare Services
Subject
Clinical Presentation
Critical Care
Mental Health
Outcome Assessment
Long Covid
Population
All
Clinical Setting
ICU
NICU
Priority Level
Level 4 Three weeks (21 days)
Cite As
Miller, L; Mueller, M. What are the one year outcomes for ICU COVID patients? 2022 Feb 10. Document no.: EOC220201 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 46 p. (CEST evidence search report).
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Document Type
Table
Review Code
EOC220201 RR Table
Question Submitted
February 7, 2022
Date Completed
February 18, 2022
Status
3. Completed
Research Team
EOC
Document Type
Table
Review Code
EOC220201 RR Table
Question Submitted
February 7, 2022
Date Completed
February 18, 2022
Status
3. Completed
Research Team
EOC
Category
Healthcare Services
Subject
Clinical Presentation
Critical Care
Mental Health
Outcome Assessment
Long Covid
Population
All
Clinical Setting
ICU
NICU
Priority Level
Level 4 Three weeks (21 days)
Cite As
Badea, A; Reeder, B; Groot, G; Miller, L; Mueller, M. What are the one year outcomes for ICU COVID patients? 2022 Feb 18, Document no.: EOC220201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. (CEST table).
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EOC220201 RR Table

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Document Type
Rapid Review
Review Code
EOC220201 RR
Question Submitted
February 7, 2022
Date Completed
February 18, 2022
Status
3. Completed
Research Team
EOC
care syndrome and Long COVID has not yet been determined. 4. Generalizability of findings: Data
Document Type
Rapid Review
Review Code
EOC220201 RR
Question Submitted
February 7, 2022
Date Completed
February 18, 2022
Status
3. Completed
Research Team
EOC
Key Findings
6-month to 1 year survival rates of critical COVID-19 patients are similar to those of non-COVID-19 patients admitted to ICU
COVID-19 patients who have survived intensive care (ICU) admission are at risk of developing both post intensive care syndrome (PICS) and Long COVID. PICS includes impairments in physical, cognitive and psychological dimensions
Long-term survival follow up of COVID patients indicates that they experience similar levels of impairments in physical, cognitive and psychological dimensions as historical non-COVID reference populations.
The most common long-term impairments reported by COVID patients are persistent dyspnea/breathlessness, general weakness/fatigue and ongoing psychological symptoms such as anxiety, depression and PTSD
Category
Healthcare Services
Subject
Clinical Presentation
Critical Care
Mental Health
Outcome Assessment
Long Covid
Population
All
Clinical Setting
ICU
NICU
Priority Level
Level 4 Three weeks (21 days)
Cite As
Badea, A; Reeder, B; Groot, G; Miller, L; Mueller, M. What are the one year outcomes for ICU COVID patients? 2022 Feb 18, Document no.: EOC220201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 11 p. (CEST rapid review report).
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Document Type
Table
Review Code
EPM210601v2 RR Table
Question Submitted
June 22, 2021
Date Completed
March 18, 2022
Status
3. Completed
Research Team
Epidemiology & Modelling
: What is the incidence and duration of long COVID cases? Review Code: EPM210601v2 RR Table Version: 2
Document Type
Table
Review Code
EPM210601v2 RR Table
Question Submitted
June 22, 2021
Date Completed
March 18, 2022
Status
3. Completed
Research Team
Epidemiology & Modelling
Category
Clinical Presentation
Epidemiology
Subject
Long Covid
Symptoms
Clinical Presentation
Population
All
Clinical Setting
Ambulatory
Community
ICU
Long Term Care
Medicine Unit
Primary care
Public Health
Priority Level
Level 1 2-3 days
Cite As
Hammond, B; Badea, A; Groot, G; Reeder, B; Howell-Spooner, B; Mueller, M. What is the incidence and duration of long COVID cases? 2022 Mar 31, Document no.: EPM210601v2 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. CEST Table
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14 records – page 1 of 2.