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Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
test, type of specimen and its quality, severity and duration of illness at the time of testing
Document Type
Rapid Review
Review Code
EPM051201 RR
Question Submitted
May 12, 2020
Date Completed
May 12, 2020
Status
3. Completed
Research Team
Epidemiology & Modelling
Key Findings
·      A wide range of tests are available for detection of viral RNA as well as serological and immunoassays for antibodies developed due to exposure to SARS CoV-2 in infected persons. Despite the emerging research, information about clinical validity of tests is limited. ·      Multiple factors affect test performance including the nature of the specific test, type of specimen and its quality, severity and duration of illness at the time of testing. These individual variations hamper assessment of diagnostic accuracy and suggest that a combination of tests on multiple types of specimens at serial time points might be needed to confirm a COVID 19 diagnosis. ·      Point of care tests are desirable and needed to scale up testing in low resource settings; however, tests are of variable quality and more research is needed before they can be relied on for clinical decision making.
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Category
Diagnostics
Subject
Antigens
Testing
Serology
Polymerase Chain Reaction
Priority Level
Level 4 completed within 1 week
Cite As
Williams-Roberts, H; Waldener, C. What is the accuracy of diagnostic tests for COVID-19 detection? 2020 May 12; Document no.: EPM051201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
EOC012601-01 ESR
Question Submitted
January 26, 2021
Date Completed
January 29, 2021
Status
3. Completed
Research Team
EOC
Evidence Search Report Review Question: How effective is surveillance antigenic testing
Document Type
Evidence Search Report
Review Code
EOC012601-01 ESR
Question Submitted
January 26, 2021
Date Completed
January 29, 2021
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Infection Prevention and Control
Subject
Screening
Antigens
Asymptomatic
Testing
Priority Level
Level 3 Two weeks (14 days)
Cite As
Dalidowicz, M; Young, C. How effective is surveillance antigenic testing? 2021 Jan 29; Document no.: EOC012601-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 32 p. (CEST evidence search report).
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Document Type
Evidence Search Report
Review Code
LAB041401-01 ESR
Question Submitted
April 14, 2020
Date Completed
April 14, 2020
Status
3. Completed
Research Team
Laboratory
on SARS-CoV-2 Laboratory Testing for the COVID-19 Pandemic (updated 2020, April 8) available from https
Document Type
Evidence Search Report
Review Code
LAB041401-01 ESR
Question Submitted
April 14, 2020
Date Completed
April 14, 2020
Status
3. Completed
Research Team
Laboratory
Category
Clinical Presentation
Subject
Testing
Antibodies
Serology
Priority Level
Level 2 completed within 8 hours
Cite As
Howell-Spooner, B. How well does the presence and level of antibodies predict the presence or absence of the disease? 2020 Apr 14; Document no.: LAB041401-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 20 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
LAB041401 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
the disease testing positive divided by the probability of a person who does not have the disease testing
Document Type
Rapid Review
Review Code
LAB041401 RR
Question Submitted
April 14, 2020
Date Completed
April 15, 2020
Status
3. Completed
Research Team
Laboratory
Key Findings
Moderate to strong grade evidence show the overall sensitivityrangeof IgM, IgG, and combined IgM/IgG are 48.1% to 94.1%, 64.7% to 100%, 83% to 100%, respectively.
IgM/IgG combined assay, with the posterior probability of 99.15%, has greater accuracyand sensitivity than a single IgM or IgG test.
The sensitivity of antibody tests is extremely low (~ 11.1%) in the first week following the onsetof symptoms but increasesrapidlyduring the second week.
IgG and IgM titers in patients with severe disease arehigher than those in the non-severe patients.
Antibody testsmay detect the presence of COVID-19 in asymptomatic individuals with negative rt-PCRresults.
Category
Clinical Presentation
Subject
Testing
Serology
Antibodies
Priority Level
Level 2 completed within 8 hours
Cite As
Wang, H; Reeder, B; Howell-Spooner, B. How well does the presence and level of antibodies predict the presence or absence of the disease? 2020 Apr 15; Document no.: LAB041401 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 9 p. (CEST rapid review report)
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EPM051201 RR
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Document Type
Table
Review Code
EOC211201 RR Table
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
participants testing with RAT at home twice weekly over 6 month period Clinical accuracy compared to PCR
Document Type
Table
Review Code
EOC211201 RR Table
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Badea, A; Reeder, B; Groot, G; Muhajarine, N; Minion, J; Miller, L; Howell-Spooner, B. In real world settings, what is the validity of Rapid Antigen Tests (RATs) in identifying SARS-CoV-2 and how well do they predict disease? 2022 Jan 12, Document no.: EOC211201 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. (CEST table).
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Document Type
Rapid Review
Review Code
EOC211201 RR
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
on the validity of RATs and thus must be used strategically in combination with other validated testing methods
Document Type
Rapid Review
Review Code
EOC211201 RR
Question Submitted
December 23, 2021
Date Completed
January 12, 2022
Status
3. Completed
Research Team
EOC
Key Findings
January 12, 2022
The diagnostic accuracy of Rapid Antigen Tests (RAT) has been widely studied in various applications and in diverse populations.
Sensitivity, in the order of 75% in pooled estimates, is significantly influenced by the presence or absence of symptoms, viral load, and the timing of sampling relative to the onset of symptoms.
Specificity, in the order of 99% in pooled estimates, is consistently high across tests, populations, and sampling methods.
Post-test probability of being an infectious case following a positive test is highest in individuals with a high pre-test probability (population prevalence > 5%), such as those with COVID-19 symptoms, and those in settings with a high level of community transmission. Here, the positive predictive value is in the order of 95%. However, when used in settings with a lower pre-test probability (population prevalence < 0.5%), as in screening asymptomatic individuals, the positive predictive value is considerably reduced, as low as 25%.
Post-test probability of being an infectious case following a negative test is less than 1% (negative predictive value > 99%) in all settings except those with the highest levels of community transmission.
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Badea, A; Reeder, B; Groot, G; Muhajarine, N; Minion, J; Miller, L; Howell-Spooner, B. In real world settings, what is the validity of Rapid Antigen Tests (RATs) in identifying SARS-CoV-2 and how well do they predict disease? 2022 Jan 12, Document no.: EOC211201 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2022. 15 p. (CEST rapid review report).
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Document Type
Evidence Search Report
Review Code
EOC211201 ESR
Question Submitted
December 23, 2021
Date Completed
December 29, 2021
Status
3. Completed
Research Team
EOC
?s_cid=mm705152e1_w  Use of Rapid Antigen Testing for SARS-CoV-2 in Remote Communities — Yukon
Document Type
Evidence Search Report
Review Code
EOC211201 ESR
Question Submitted
December 23, 2021
Date Completed
December 29, 2021
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Epidemiology
Subject
Antigens
Infection Prevention and Control
Testing
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Miller, L. & Howell-Spooner, B. In real world settings, what is the validity of RATs in identifying COVID-19 (sensitivity, specificity), and how well do they predict disease (positive and negative predictive values)? 2021 Dec 29, Document no.: EOC211201 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 56 p. (CEST evidence search report).
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Document Type
Evidence Search Report
Review Code
EOC081301-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
QUESTION: Is pooled testing for COVID-19 equally as reliable as individual testing and what
Document Type
Evidence Search Report
Review Code
EOC081301-01 ESR
Question Submitted
August 12, 2020
Date Completed
August 12, 2020
Status
3. Completed
Research Team
EOC
Category
Diagnostics
Subject
Testing
Public Health
Decision Making
Priority Level
Level 3 completed within 2-3 days
Cite As
Dalidowicz, M. Is pooled testing for COVID-19 equally as reliable as individual testing and what are the optimal pool testing sizes? 2020 Aug 12; Document no.: EOC081301-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 8 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
EOC081301 RR
Question Submitted
August 12, 2020
Date Completed
August 14, 2020
Status
3. Completed
Research Team
EOC
Review Title: Is pooled testing for COVID-19 equally as reliable as individual testing and what
Document Type
Rapid Review
Review Code
EOC081301 RR
Question Submitted
August 12, 2020
Date Completed
August 14, 2020
Status
3. Completed
Research Team
EOC
Key Findings
· Pool testing for COVID-19 can be equal to individual testing in terms of sensitivity, specificity and positive and negative prediction rates · Pooled testing is optimal for use when disease prevalence is low, as prevalence increases, optimal pool sizes decrease and efficiency is lost · At a prevalence of approximately 1%, optimal pool sizes have been found to be up to 13 · Pools of 5 were found to be equally efficient and could be done using 50% less tests up to a prevalence of 5% · Recommended for use in large scale asymptomatic screening, highest viral load occurs before symptoms so less likely to miss borderline positive in convalescent stage · Not recommended for clinical diagnostic use
Category
Diagnostics
Subject
Testing
Public Health
Decision Making
Priority Level
Level 3 completed within 2-3 days
Cite As
Badea, A; Muhajarine, N; Dalidowicz, M. Is pooled testing for COVID-19 equally as reliable as individual testing and what are the optimal pool testing sizes? 2020 Aug 14; Document no.: EOC081301 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 19 p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
LAB040803-01 ESR
Question Submitted
April 8, 2020
Date Completed
April 8, 2020
Status
3. Completed
Research Team
Laboratory
screening method. As an effective supplement to RNA testing, antibody detection is of epidemiological
Document Type
Evidence Search Report
Review Code
LAB040803-01 ESR
Question Submitted
April 8, 2020
Date Completed
April 8, 2020
Status
3. Completed
Research Team
Laboratory
Category
Clinical Presentation
Subject
Testing
Serology
Immunity
Natural History
Population
All
Priority Level
Level 2 completed within 8 hours
Cite As
Duncan, V. Is the IgM or IgG immune response protective? 2020 Apr 8; Document no.: LAB040803-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 13 p. (CEST evidence search report)
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32 records – page 1 of 4.