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Document Type
Rapid Review
Review Code
PH030801 RR
Question Submitted
March 8, 2021
Date Completed
March 30, 2021
Status
6. Cancelled
Research Team
Public Health
Review Title: What are the effects of the new COVID variants on transmission and school reopenings
Document Type
Rapid Review
Review Code
PH030801 RR
Question Submitted
March 8, 2021
Date Completed
March 30, 2021
Status
6. Cancelled
Research Team
Public Health
Key Findings
Pediatric cases of COVID-19 constitute between 1% to 10% of all confirmed cases of COVID-19; variation exists by jurisdiction.
Few case reports exist of confirmed child-to-other transmission. Contact tracing studies suggest that children are unlikely to be transmitters of the disease. Households are the most likely environments for transmission.
A recent large South Korean contact tracing study however (in pre-print) found that household COVID-19 transmission rates for children age 10-19 were significantly higher than in adults; transmission rates for children age 0-9 were relatively low.
AUGUST 7th, 2020 UPDATE: No new studies examining secondary attack rates of pediatric index cases were found. Studies continue to suggest low transmission from pediatric cases, and high proportion of pediatric cases being asymptomatic to mildly symptomatic.
MARCH 9th, 2021 UPDATE: Variants of Concerns are an emerging threat, but literature on pediatric prevalence and transmissibility is sparse. The British variant seems more transmissible (secondary attack rate higher) but follows the same age-related distribution of cases seen earlier in the pandemic.
Category
Epidemiology
Infection Prevention and Control
Subject
Vaccines
Variants
Pediatrics
Transmission
Schools
Population
All Pediatrics
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Sulaiman, F; Coomaran, V; Muhajarine, N; Dalidowicz, M; Miller, L. What are the effects of the new COVID variants on transmission and school reopenings in pediatric populations? 2021 Mar 30; Document no.: PH030801 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 14p. (CEST rapid review report)
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Document Type
Evidence Search Report
Review Code
PH030801v2 ESR
Question Submitted
March 8, 2021
Date Completed
August 18, 2021
Status
6. Cancelled
Research Team
Public Health
EVIDENCE SEARCH REPORT Review Question: What are the effects of the new COVID variants on transmission
Document Type
Evidence Search Report
Review Code
PH030801v2 ESR
Question Submitted
March 8, 2021
Date Completed
August 18, 2021
Status
6. Cancelled
Research Team
Public Health
Notes
Work was not completed before the project was no longer supported
Category
Epidemiology
Infection Prevention and Control
Subject
Variants
Pediatrics
Transmission
Schools
Population
All Pediatrics
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Howell-Spooner, B., Mueller, M. What are the effects of the new COVID variants on transmission and school reopenings in pediatric populations? 2021 Aug 18, Document no.: PH030801v2 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 49 p. (CEST evidence search report).
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EOC072102-01 ESR
EOC070201v2-01 ESR
EOC081201-01 ESR
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Document Type
Evidence Search Report
Review Code
EOC022201-01 ESR
Question Submitted
February 22, 2021
Date Completed
February 22, 2021
Status
3. Completed
Research Team
EOC
Evidence Search Report Review Question: What is the epidemiology of variants and what
Document Type
Evidence Search Report
Review Code
EOC022201-01 ESR
Question Submitted
February 22, 2021
Date Completed
February 22, 2021
Status
3. Completed
Research Team
EOC
Category
Epidemiology
Healthcare Services
Subject
Variants
Health Planning
Population
All
Clinical Setting
Other
All
Priority Level
Level 3 Two weeks (14 days)
Cite As
Miller, L; Young, C. What is the epidemiology of variants and what are the implications for healthcare? 2021 Feb 22; Document no.: EOC022201-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 28 p. (CEST evidence search report)
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Document Type
Rapid Review
Review Code
EOC031801v017 RR
Question Submitted
March 18, 2021
Date Completed
November 23, 2021
Status
5. Updated review
Research Team
EOC
Support Team RAPID REVIEW REPORT What is the epidemiology of variants and what are the implications
Document Type
Rapid Review
Review Code
EOC031801v017 RR
Question Submitted
March 18, 2021
Date Completed
November 23, 2021
Status
5. Updated review
Research Team
EOC
Updated Key Findings
November 23, 2021 - Delta dominance - Delta continues to account for most of variants sequenced from surveillance data from Public Health Ontario, Public Health England and ECDC. - The Delta sub-lineage AY.4.2 (Delta plus) accounts for a slowly increasing proportion of Delta cases in the UK. However, evidence is still emerging on its effect on vaccine efficacy and disease severity. - Increased disease severity (hospitalization) has been observed in adults 18 to 49 years during Delta variant dominance and has been attributed to the low vaccination rates among this age group. - Epidemiological models predict a new wave of infection if measures such as NPIs are relaxed due to changes in immune escape capability and transmissibility of variants. - While of moderate certainty, evidence exists to suggest the Delta variant is associated with a higher secondary attack rate, especially among unvaccinated populations.
Key Findings
November 12, 2021 - Emerging data suggest the Delta variant can initiate fast-rising outbreaks in populations with immune responses to prior variants, resulting in reinfections and vaccination breakthroughs. However, we have low certainty of evidence at this point. - A quarter of Delta-associated outbreaks in Ontario were reported in elementary school settings for the week of September 12 to September 18, 2021. - Full vaccination against COVID-19 has been reported to be more effective in protecting against Delta infection and severe illness (hospitalization and ICU admissions) than partial vaccination. - Effective protection for essential workers and prompt surveillance of occupational health in the workplace are needed due to disproportionate Delta variant infection among workers such as cleaners. - While the certainty is low, evidence exists to suggest that a lower gross domestic product (GDP) per capita, higher diabetes prevalence, higher cardiovascular disease rate, and lower percentage of fully vaccinated people have been reported as predictors of higher Delta variant Case Fatality Rate (CFR)
Category
Epidemiology
Healthcare Services
Subject
Health Planning
Variants
Population
All
Clinical Setting
Community
Public Health
Priority Level
Level 3 Two weeks (14 days)
Cite As
Asamoah, G; Badea, A; Lee, S; Shumilak, G; Reeder, B; Groot, G; Muhajarine, N; Hernandez-Ronquillo L; Miller, L; Howell-Spooner, B. What is the epidemiology of variants and what are the implications for healthcare? 2021 Nov 23. Document no.: EOC031801v017 RR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. 48 p. (CEST rapid review report).
Review History
EOC031801v16 RR
EOC031801v15 RR
EOC031801v14 RR
v012 and v013 RR were combined into v013
EOC031801v011 RR: August 27, 2021
v010 and v011 RR were combined into v011
EOC031801v9 RR: August 19, 2021
EOC031801v8 RR: July 12, 2021
EOC031801v7 RR; June 24, 2021
EOC031801v6 RR; June 17, 2021
EOC031801v5 RR; June 2, 2021
EOC031801v4 RR; May 17, 2021
EOC031801v3 RR: May 3, 2021
EOC031801v2 RR: April 20, 2021
EOC031801 RR: March 25, 2021
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Less detail
Document Type
Table
Review Code
EOC031801v017 RR Table
Question Submitted
March 18, 2021
Date Completed
November 23, 2021
Status
5. Updated review
Research Team
EOC
: What is the epidemiology of variants and what are the implcations for healthcare? Review Code
Document Type
Table
Review Code
EOC031801v017 RR Table
Question Submitted
March 18, 2021
Date Completed
November 23, 2021
Status
5. Updated review
Research Team
EOC
Category
Epidemiology
Healthcare Services
Subject
Health Planning
Variants
Population
All
Clinical Setting
Community
Public Health
Priority Level
Level 3 Two weeks (14 days)
Cite As
Asamoah, G; Badea, A; Hernandez-Ronquillo, L; Lee, S; Shumilak, G; Reeder, B; Groot, G; Muhajarine, N; Miller, L; Howell-Spooner, B. What is the epidemiology of variants and what are the implications for healthcare? 2021 Nov 23. Document no.: EOC031801v017 RR Table. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2021. (CEST table).
Review History
EOC031801v16 RR
EOC031801v15 RR
EOC031801v14 RR
v012 and v013 RR were combined into v013
EOC031801v011 RR: August 27, 2021
v010 and v011 RR were combined into v011
EOC031801v9 RR: August 19, 2021
EOC031801v8 RR: July 12, 2021
EOC031801v7 RR; June 24, 2021
EOC031801v6 RR; June 17, 2021
EOC031801v5 RR; June 2, 2021
EOC031801v4 RR; May 17, 2021
EOC031801v3 RR: May 3, 2021
EOC031801v2 RR: April 20, 2021
EOC031801 RR: March 25, 2021
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EOC031801v017 RR Table

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Less detail
Document Type
Evidence Search Report
Review Code
INF123001-01 ESR
Question Submitted
December 30, 2020
Date Completed
December 31, 2020
Status
5. Updated review
Research Team
Infectious Disease
. Risk Assessment: Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA. [2020
Document Type
Evidence Search Report
Review Code
INF123001-01 ESR
Question Submitted
December 30, 2020
Date Completed
December 31, 2020
Status
5. Updated review
Research Team
Infectious Disease
Category
Epidemiology
Subject
Variants
Population
All
Clinical Setting
Public Health
Priority Level
Level 2 One week (7 days)
Cite As
Howell-Spooner, B; Miller, L. What is the R0 (basic reproduction number) of the new coronavirus variant detected in the UK? 2020 Dec 31; Document no.: INF123001-01 ESR. In: COVID-19 Rapid Evidence Reviews [Internet]. SK: SK COVID Evidence Support Team, c2020. 8 p. (CEST evidence search report)
Review History
INF123001 RR: January 4, 2021
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6 records – page 1 of 1.